Saturday, May 11, 2019

Alzheimer's - Current research and treatments Paper

Alzheimers - current and treatments - seek Paper practiceBeta gritty protein damage cells by converting oxygen into hydrogen peroxide bleach that corrode thinker cells, interfere with message relays in the brain and signaling the cell to self-destruction (Patterson et al 120). In unison to Patterson, Feightner and Garcia, there is a transition from epidemiologic observation to rigorous clinic test trials on Alzheimers patients which is of import in understanding the most beneficial treatments amyloid Hypothesis is undergoing analysts alongside many trails aimed at trim amyloid and plague which be completes and are in testing phases. Ways researched and documented are anti aggregation agents, immunotherapeutic trials and modulation of secretases apply in beta amyloid production. The major therapies of hyper-phosphorylated tau and novel targets are under research these therapies target the enhancement of serotonin receptor, factors of nerve growth, mitochondrial function enha ncement, and advanced gyration products receptor. Boothby and Doering enunciate that Current scientific research and the treatment of Alzheimers c everywheres four core areas. First is to increase efficiencies of shamed nerves, donepezil hydrochloride and memantine hydrochloride drugs are used. They foster the cell efficiencies though their effect is short lived. Secondly, is inhibiting manufacture of beta amyloid proteins. Current experiments are performed to determine a molecule that counters the process of the parent beta amyloid protein (Patterson et al, 120). This is aimed at lessen the production of these proteins. Subsequently a lots of research work concentrates on ways of inhibiting beta amyloid build up within cells. Patterson, Feightner, and Garcia Scientists theorize that the beta amyloid become toxic with each build-up, then if broken down at an earlier stage, they become less toxic. Lastly, clinical studies are aiming at shield nerve cells form hydrogen peroxide e ffects. Use of vitamin E as a shield shows comminuted but impacting improvement in a group of Alzheimers patients. A range of antioxidants is being tried in research labs to determine if they can protect the cells. Though minerals such as copper compact and zinc metals are essential for brain functions, there is continued research on ways to prevent the minerals interacting with brain cells. Though treatments may be available, it is paramount to see that the disease risk factors are observed and prevented. Such risk factors are cholesterol, high squanderer pressure, Diabetes, gender hormones, brain activity, physical activity and antioxidants and nutrition. Research shows that cholesterol increases the blood pressure hence aggravating the risk of blood pressure. Statin drugs are used to lower blood cholesterol though clinical studies depict them as ineffective if used over a long period. Alternative research studies have shown that amino acid homocsyteine increase the risk of developing Alzheimers. Meanwhile, High blood pressure has a link between stroke and Alzheimers disease. High blood pressure damages blood vessels hence reducing the brain oxygen supply (Neugroschl and Sano 129). The Resultant oxidative stress speeds up the production of amyloid protein. Subsequently, Diabetes is majorly associated with different type of dementia i.e. Alzheimers and vascular dementia. Both Diabetes and Alzheimers translucent similar characteristics in the elderly, that is deposits of amyloid protein in brain and pancreas. Women possess

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